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2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (122520-85-8)

Identification
Name:2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)-
Synonyms:2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-, (E)-; AG 99; AG 99 (enzyme inhibitor);Tyrphostin 46
CAS:122520-85-8
Molecular Formula: C10H8 N2 O3
Molecular Weight: 204.18
InChI: InChI=1S/C10H8N2O3/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+
Molecular Structure: (C10H8N2O3) 2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-, (E)-; AG 99; AG 99 (enzyme inhibitor);Tyrphostin 46
Properties
Flash Point: 283°C
Boiling Point: 544.4°Cat760mmHg
Density:1.482g/cm3
Biological Activity: Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 10 μ M) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145 met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro .
Flash Point: 283°C
Safety Data
 

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