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2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-, (2E)- (133550-30-8)

Identification
Name:2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-, (2E)-
Synonyms:2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-, (E)-;AG 490;Tyrphostin AG490;(2E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide;
CAS:133550-30-8
Molecular Formula: C17H14N2O3
Molecular Weight: 294.10
InChI: InChI=1/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
Molecular Structure: (C17H14N2O3) 2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-, (E)-;AG 490;Tyrphostin AG490;(2E)-N...
Properties
Density:1.337 g/cm3
Refractive index:1.678
Water Solubility:Soluble in DMSO and acetone; slightly soluble in 100% ethanol
Solubility:Soluble in DMSO and acetone; slightly soluble in 100% ethanol
Appearance:Yellow solid
Biological Activity: Selective inhibitor of EGF receptor tyrosine kinase (IC 50 values are 2 and 13.5 μ M for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo .
Color: yellow
Safety Data
Hazard Symbols Xi: Irritant
 

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