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2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1R)-1-phenylethyl]-, (2E)- (133550-32-0)

Identification
Name:2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1R)-1-phenylethyl]-, (2E)-
Synonyms:2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-(1-phenylethyl)-, [R-(E)]-; Tyrphostin AG527; Tyrphostin B 44
CAS:133550-32-0
Molecular Formula: C18H16 N2 O3
Molecular Weight: 308.33
InChI: InChI=1/C18H16N2O3/c1-12(14-5-3-2-4-6-14)20-18(23)15(11-19)9-13-7-8-16(21)17(22)10-13/h2-10,12,21-22H,1H3,(H,20,23)/b15-9+/t12-/m1/s1
Molecular Structure: (C18H16N2O3) 2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-(1-phenylethyl)-, [R-(E)]-; Tyrphostin AG527; Tyrpho...
Properties
Flash Point: 318.5°C
Boiling Point: 603°C at 760 mmHg
Density:1.299g/cm3
Refractive index:1.66
Biological Activity: Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC 50 = 0.4 μ M), more active than the (+) enantiomer ((S)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide ). Selective over ErbB2.
Flash Point: 318.5°C
Storage Temperature: −20°C
Safety Data
 

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