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2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]-, (2E)- (133550-37-5)

Identification
Name:2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]-, (2E)-
Synonyms:2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-(1-phenylethyl)-, [S-(E)]-; Tyrphostin AG835; Tyrphostin B 50
CAS:133550-37-5
Molecular Formula: C18H16 N2 O3
Molecular Weight: 308.33
InChI: InChI=1/C18H16N2O3/c1-12(14-5-3-2-4-6-14)20-18(23)15(11-19)9-13-7-8-16(21)17(22)10-13/h2-10,12,21-22H,1H3,(H,20,23)/b15-9+/t12-/m0/s1
Molecular Structure: (C18H16N2O3) 2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-(1-phenylethyl)-, [S-(E)]-; Tyrphostin AG835; Tyrpho...
Properties
Flash Point: 318.5°C
Boiling Point: 603°Cat760mmHg
Density:1.299g/cm3
Refractive index:1.66
Biological Activity: Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 0.86 μ M). Slightly less active than the (-) enantiomer ((R)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide ).
Flash Point: 318.5°C
Storage Temperature: −20°C
Safety Data
 

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